For amoxicillin administration at a dosage of 500 mg PO, where the available concentration is 250 mg/5 mL, how much should be given per dose?

To determine the correct volume of amoxicillin to administer for a 500 mg dose when the concentration available is 250 mg per 5 mL, it's essential to use a straightforward calculation based on the dosage required and the concentration available.

The first step is to find out how many milligrams are there in 1 mL of the solution. Since 250 mg is contained in 5 mL, you can calculate the concentration per mL:

1. Calculate the concentration:
   • 250 mg / 5 mL = 50 mg/mL

Next, to find out how many mL are needed to achieve the desired 500 mg dose, you can set up a proportion based on the concentration you just calculated:

2. Use the concentration to find the required volume for 500 mg:
   • Volume = Desired dose / Concentration per mL
   • Volume = 500 mg / 50 mg/mL = 10 mL

This shows that in order to deliver a dose of 500 mg, a total of 10 mL of the amoxicillin solution is needed. Hence, the correct answer is that 10 mL should be given per dose.